反应详情

A mixture of 4-chloropyridine hydrochloride (4.50 g), 2-(methylamino)ethanol (2.25 g) and sodium bicarbonate (7.56 g) in isoamyl alcohol (50 ml) was heated under reflux for 70 hours and then evaporated. The residue was extracted several times with hot ethyl acetate and the combined extracts were filtered and evaporated until crystallisation commenced. The solution was allowed to cool and the solid was filtered off to give the title compound, (0.85 g), m.p. 90°-91°.

1. temperaturewas heated
2. temperatureunder reflux for 70 hours
3. customevaporated
4. extractionThe residue was extracted several times with hot ethyl acetate
5. filtrationthe combined extracts were filtered
6. customevaporated until crystallisation
7. temperatureto cool
8. filtrationthe solid was filtered off