Methyl iodide → HCID 15086005, compound

HRID 1073221Notes

Reaction equation

HRID 1073221 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]2[N:8]([C:9]=1[CH2:10][OH:11])[C:7]1[CH:12]=[CH:13][CH:14]=[CH:15][C:6]=1[S:5]2.[H-].[Na+].[CH3:18]I>CN(C)C=O>[CH3:18][O:11][CH2:10][C:9]1[N:8]2[C:4]([S:5][C:6]3[CH:15]=[CH:14][CH:13]=[CH:12][C:7]=32)=[N:3][C:2]=1[CH3:1]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 130922Nik 228

Product 1

HCID 15086005HCID 15086005, compoundYield 60.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In 30 ml of dry dimethylformamide was suspended 2.18 g of 2-methylimidazo[2,1-b]benzothiazole-3-methanol and, 0.50 g of 60% sodium hydride was added to the suspension followed by stirring at room temperature for minutes. After 1.74 g of methyl iodide was added thereto, the mixture was stirred for one hour. Then ice water was added to the reaction mixture followed by extracting with ethyl acetate. After the ethyl acetate was removed, 1.41 g of the title compound was obtained.

Workup

  1. additionwas added to the suspension
  2. stirringthe mixture was stirred for one hour
  3. extractionby extracting with ethyl acetate
  4. customAfter the ethyl acetate was removed

Sources & evidence

ORD record
ord-01542132dd454ae284a8761c91dbed3c
Source dataset
uspto-grants-1990_11
Patent number
US04968708

Reaction notes

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