Dimethylformamide → HCID 70373830, compound

HRID 1073223Notes

Reaction equation

HRID 1073223 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]2[N:8]([C:9]=1[CH2:10][OH:11])[C:7]1[CH:12]=[CH:13][CH:14]=[CH:15][C:6]=1[S:5]2.[H-].[Na+].[C:18]1(C(Cl)=O)[S:22][CH:21]=[CH:20][CH:19]=1.CN(C)[CH:28]=[O:29]>>[CH3:1][C:2]1[N:3]=[C:4]2[N:8]([C:9]=1[CH2:10][O:11][C:28](=[O:29])[C:20]1[CH:19]=[CH:18][S:22][CH:21]=1)[C:7]1[CH:12]=[CH:13][CH:14]=[CH:15][C:6]=1[S:5]2

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 24758Sodium hydrideHCID 789282-Thiophenecarbonyl chlorideHCID 130922Nik 228

Product 1

HCID 70373830HCID 70373830, compound

Procedure

In 30 ml of dry dimethylformamide was suspended 2.18 g of 2-methylimidazo[2,1-b]benzothiazole-3-methanol. Then, 0.50 g of 60% sodium hydride was added to the suspension. After stirring for 30 minutes, 1.76 g of thenoyl chloride was added to the mixture followed by stirring at room temperature for 3 hours. Ice water was added to the reaction mixture and the system extracted with chloroform. After the chloroform was removed, 1.76 g of the title compound was obtained.

Workup

  1. stirringby stirring at room temperature for 3 hours
  2. extractionthe system extracted with chloroform
  3. customAfter the chloroform was removed

Sources & evidence

ORD record
ord-7cdbcdc4c7184503ae33e30745663714
Source dataset
uspto-grants-1990_11
Patent number
US04968708

Reaction notes

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