Water → HCID 15085981, compound

HRID 1073282Notes

Reaction equation

HRID 1073282 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=O.Cl.[NH2:14][CH2:15][C:16]([C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)=[CH:20][CH:19]=1)=O.[OH2:31]>>[NH2:14][C:15]1[C:16]([C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=3)=[CH:20][CH:19]=2)=[N:7][C:8]2[C:4]([C:5]=1[C:6]([OH:11])=[O:31])=[CH:3][C:2]([Cl:1])=[CH:10][CH:9]=2

Participants

4

Reactant 3

HCID 962WaterHCID 872035-chloro-1H-indole-2,3-dioneHCID 22158358HCID 22158358, compound

Product 1

HCID 15085981HCID 15085981, compound

Procedure

A basic aqueous solution of 4.54 g of 5-chloroisatin in water was reacted with 9.0 g of 2-amino-1-(4'-fluoro-[1,1'-biphenyl]-4-yl)ethanone hydrochloride by the procedure described in example 20, giving 6.2 g of the desired compound as a yellow solid, mp 255°-257° C.

Sources & evidence

ORD record
ord-813b3791bfc04b4cbce32dd63e126e42
Source dataset
uspto-grants-1990_11
Patent number
US04968702

Reaction notes

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