Potassium Cyanide → HCID 10081707, compound

HRID 1073351Notes

Reaction equation

HRID 1073351 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([C:9]2[CH:14]=[CH:13][N:12]=[C:11](S(C)(=O)=O)[N:10]=2)[CH:6]=[CH:7][CH:8]=1)#[N:2].[C-:19]#[N:20].[K+]>CN(C)C=O>[C:19]([C:11]1[N:10]=[C:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:1]#[N:2])[CH:4]=2)[CH:14]=[CH:13][N:12]=1)#[N:20]

Participants

4

Reactant 2

HCID 9032Potassium CyanideHCID 10061103HCID 10061103, compound

Product 1

HCID 10081707HCID 10081707, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 4-(3-cyanophenyl)-2-methylsulfonylpyrimidine and potassium cyanide in N,N-dimethylformamide is stirred for 4 hours at 100° . The reaction mixture is concentrated by evaporation, distilled water is added thereto and the whole is extracted with methylene chloride. The organic phase is dried and concentrated by evaporation to give the title compound.

Workup

  1. concentrationThe reaction mixture is concentrated by evaporation
  2. distillationdistilled water
  3. additionis added
  4. extractionthe whole is extracted with methylene chloride
  5. customThe organic phase is dried
  6. concentrationconcentrated by evaporation

Sources & evidence

ORD record
ord-cf055399cc964277b3f14d10f23b268e
Source dataset
uspto-grants-1990_11
Patent number
US04968804

Reaction notes

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