反应详情

To a mixture of 2.30 g of 4-cyano-N-methylbenzenesulfonamide, 2.40 g of α-(bromomethyl)styrene and 20 ml of N,N-dimethylformamide, 0.63 g of 50% sodium hydride (oil dispersed) was slowly added with stirring under ice cooling, then the mixture was stirred at room temperature for 6 hours. After evaporating the solvent under a reduced pressure, ethyl acetate was added to the residue. The organic layer was washed with water and dried over anhydrous sodium sulfate. After distilling off the solvent, the residue was purified by silica gel column chromatography (developing solvent: ethyl acetate n-hexane) to obtain 1.70 g of the titled compound.

1. additionwas slowly added
2. stirringthe mixture was stirred at room temperature for 6 hours
3. customAfter evaporating the solvent under a reduced pressure, ethyl acetate
4. additionwas added to the residue
5. washThe organic layer was washed with water
6. dry with materialdried over anhydrous sodium sulfate
7. distillationAfter distilling off the solvent
8. customthe residue was purified by silica gel column chromatography (developing solvent: ethyl acetate n-hexane)