Diisopropyl Ether → HCID 10094518, compound

HRID 1073767Notes

Reaction equation

HRID 1073767 reaction equation
Cl[CH2:2][C:3]([N:5]1[C:11]2[CH:12]=[CH:13][C:14]([CH3:16])=[CH:15][C:10]=2[C:9](=[O:17])[NH:8][C:7]2[CH:18]=[CH:19][CH:20]=[N:21][C:6]1=2)=[O:4].[CH2:22]([N:24]([CH2:27][CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][NH:29]1)[CH2:25][CH3:26])[CH3:23].C(OC(C)C)(C)C>C(#N)C>[CH2:22]([N:24]([CH2:27][CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][N:29]1[CH2:2][C:3]([N:5]1[C:11]2[CH:12]=[CH:13][C:14]([CH3:16])=[CH:15][C:10]=2[C:9](=[O:17])[NH:8][C:7]2[CH:18]=[CH:19][CH:20]=[N:21][C:6]1=2)=[O:4])[CH2:25][CH3:26])[CH3:23]

Participants

5

Reactant 3

HCID 7914Diisopropyl EtherHCID 254287N,N-Diethyl-2-piperidinemethanamineHCID 14075459HCID 14075459, compound

Product 1

HCID 10094518HCID 10094518, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Prepared in analogy to Example 2 from 11-(chloroacetyl)-5,11-dihydro-8-methyl-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[(diethylamino)methyl]piperidine, but using acetonitrile as solvent, in a yield of 54% of theory. M.p. 173-174° C. (diisopropylether).

Sources & evidence

ORD record
ord-432754fce64e433a96372f2c16b39923
Source dataset
uspto-grants-1990_11
Patent number
US04971966

Reaction notes

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