Phenyl isocyanate → HCID 14459255, compound

HRID 1074169Notes

Reaction equation

HRID 1074169 reaction equation
[C:1]1([N:7]=[C:8]=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[F:11][C:12]1[CH:17]=[CH:16][C:15]([C:18](=[O:22])[CH2:19][NH:20][CH3:21])=[CH:14][CH:13]=1.C(N(CC)CC)C>C1(C)C=CC=CC=1>[F:11][C:12]1[CH:13]=[CH:14][C:15]([C:18](=[O:22])[CH2:19][N:20]([CH3:21])[C:8]([NH:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[O:9])=[CH:16][CH:17]=1

Participants

5

Reactant 3

HCID 7672Phenyl isocyanateHCID 8471TriethylamineHCID 14459254HCID 14459254, compound

Product 1

HCID 14459255HCID 14459255, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
25 °C

Procedure

1.26 g (12.5 mmol) of phenyl isocyanate are used to a suspension of 3 g (12.5 mmol) of the compound from Example 2 in 30 ml of toluene and 1.5 g (12.5 mmol) of triethylamine are slowly added dropwise at 0° C. The mixture is stirred overnight at 25° C. The toluene phase is washed with water, the product precipitating out. After drying 3.54 g are obtained.

Workup

  1. additionare slowly added dropwise at 0° C
  2. washThe toluene phase is washed with water
  3. customthe product precipitating out
  4. customAfter drying 3.54 g
  5. customare obtained

Sources & evidence

ORD record
ord-518b170b29c14136ae47260d50c32943
Source dataset
uspto-grants-1990_11
Patent number
US04973598

Reaction notes

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