反应详情

19.3 g of an aqueous 10% sodium hypochlorite solution are added to a solution of 3.9 g of α-(1-methylpyrazol-5-yl)-2,3-dichloro-4,5-dimethoxybenzylalcohol in acetic acid and the mixture is stirred at room temperature for 2 hours. The reaction mixture is concentrated to remove acetic acid, and ethyl acetate is added to the residue. The organic layer is separated, washed with water, dried and evaporated to remove solvent. The residue is purified by silica gel column chromatography to give 2.1 g of (1-methyl-4-chloropyrazol-5-yl)-(2,3-dichloro-4,5-dimethoxyphenyl)-methanone.

1. concentrationThe reaction mixture is concentrated
2. customto remove acetic acid, and ethyl acetate
3. additionis added to the residue
4. customThe organic layer is separated
5. washwashed with water
6. customdried
7. customevaporated
8. customto remove solvent
9. customThe residue is purified by silica gel column chromatography