反应详情

Into a 200 ml egg-plant type flask, 785.2 mg (4.06 mmol) of 2-chloropyridine-6-sulfonic acid was charged, then dissolved with an addition of 2 ml of water and neutralized with an aqueous lithium hydroxide solution. The solvent was distilled off under reduced pressure, and after an addition of 100 ml of 2-propanol, the mixture was heated. Insoluble matters were removed by filtration, and the solvent was distilled under reduced pressure to obtain 725 mg (89.5%) of lithium 2-chloropyridine-6-sulfonate as crystalline solid. Purification was conducted by recrystallization from 2-propanol.

1. distillationThe solvent was distilled off under reduced pressure
2. additionafter an addition of 100 ml of 2-propanol
3. temperaturethe mixture was heated
4. customInsoluble matters were removed by filtration
5. distillationthe solvent was distilled under reduced pressure