Dimethylformamide dimethyl acetal → HCID 54542368, compound

HRID 1074602Notes

Reaction equation

HRID 1074602 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:3]=1[NH:4][C:5](=[O:9])[CH2:6][C:7]#[N:8].CO[CH:17](OC)[N:18]([CH3:20])[CH3:19]>>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:3]=1[NH:4][C:5](=[O:9])[C:6]([C:7]#[N:8])=[CH:17][N:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 3644962N-(2-chloro-4-fluorophenyl)-2-cyanoacetamide

Product 1

HCID 54542368HCID 54542368, compound

Procedure

As for Example 1, 2'-chloro-2-cyano-4'-fluoroacetanilide as colorless needles, m.p. 138°-139° C. (prepared by the procedure described in U.S. Pat. No. 3,116,312), is heated with N,N-dimethylformamide dimethylacetal to give 2'-chloro-2-cyano-3-dimethylamino-4'-fluoroacrylanilide as colorless needles, m.p. 155.5°-156.5° C.

Sources & evidence

ORD record
ord-ed5255fb38084eaf9f39eb8bd31e9fcc
Source dataset
uspto-grants-1983_07
Patent number
US04393217

Reaction notes

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