反应详情

Then, 14.9 g of 2-(3-chloropropyl)-4-phenyl-1(2H)-isoquinolone, 7 g of anhydrous potassium carbonate and 40 ml of piperidine were mixed and heated at reflux for 5 hours. Thereafter, any excess of piperidine was distilled off and the residue was dissolved in dichloromethane. The solution was washed with water, dried and the solvent was distilled off. The resulting crystals were recrystallized from a mixture of diethyl ether and petroleum ether to obtain 15.6 g of 2-(3-piperidinopropyl)-4-phenyl-1(2H)-isoquinolone having a melting point of 117.5° C. as colorless prisms.

1. temperatureheated
2. temperatureat reflux for 5 hours
3. distillationThereafter, any excess of piperidine was distilled off
4. dissolutionthe residue was dissolved in dichloromethane
5. washThe solution was washed with water
6. customdried
7. distillationthe solvent was distilled off
8. customThe resulting crystals were recrystallized from a mixture of diethyl ether and petroleum ether