Hydrochloric Acid → HCID 13151855, compound

HRID 1074997Notes

Reaction equation

HRID 1074997 reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[C:12](=[O:13])[CH2:11][C:10]3[CH:14]=[CH:15][CH:16]=[CH:17][C:9]=3[S:8](=[O:18])[C:7]=2[CH:19]=1)#N.[OH-:20].[Na+].C(O)C.Cl.[OH2:26]>>[O:13]=[C:12]1[CH2:11][C:10]2[CH:14]=[CH:15][CH:16]=[CH:17][C:9]=2[S:8](=[O:18])[C:7]2[CH:19]=[C:3]([C:1]([OH:26])=[O:20])[CH:4]=[CH:5][C:6]1=2

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 702EthanolHCID 962WaterHCID 14798Sodium HydroxideHCID 13151865HCID 13151865, compound

Product 1

HCID 13151855HCID 13151855, compound

Procedure

780 Mg. 3-cyano-10,11-dihydro-11-oxodibenzo[b,f]thiepin 5-oxide is refluxed for four hours in a mixture of 50 cc. 10% aqueous sodium hydroxide and 50 cc. ethanol. The reaction mixture is diluted with water, acidified with hydrochloric acid, filtered and dried under vacuum in the oven at 70° C. The solid is recrystallized from a mixture of dimethylformamide and methanol to yield 360 mg. of the pure acid, m.p. 273° C. dec.

Workup

  1. filtrationfiltered
  2. customdried under vacuum in the oven at 70° C
  3. customThe solid is recrystallized from a mixture of dimethylformamide and methanol
  4. customto yield 360 mg

Sources & evidence

ORD record
ord-383662f1f56f4165b9b62be615e7949a
Source dataset
uspto-grants-1983_07
Patent number
US04394515

Reaction notes

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