反应详情

400 Mg. 8-chloro-3-cyanodibenzo[b,f]thiepin is dissolved in 30 cc. chloroform and 2 g. m-chloroperbenzoic acid added, and the solution stirred for 24 hours. 5 G. calcium hydroxide is added, the mixture stirred for five minutes and filtered through celite. The organic filtrate is evaporated to dryness and the residue chromatographed on silica gel and eluted with 5% ethyl acetate/benzene mixture to yield 339 mg. (76%) pure sulfone, m.p. 228°-230° C.

1. stirringthe mixture stirred for five minutes
2. filtrationfiltered through celite
3. customThe organic filtrate is evaporated to dryness
4. customthe residue chromatographed on silica gel
5. washeluted with 5% ethyl acetate/benzene mixture
6. customto yield 339 mg