1-Iodopropane → 1-Propyl-5-fluoropyrimid-2-one

HRID 1075140Notes

Reaction equation

HRID 1075140 reaction equation
[K].[F:2][C:3]1[CH:4]=[N:5][C:6](=[O:9])[NH:7][CH:8]=1.[CH2:10](I)[CH2:11][CH3:12]>>[CH2:10]([N:5]1[CH:4]=[C:3]([F:2])[CH:8]=[N:7][C:6]1=[O:9])[CH2:11][CH3:12]

Participants

4

Reactant 3

HCID 336431-IodopropaneHCID 1014985-Fluoropyrimidin-2-oneHCID 5462222Potassium

Product 1

HCID 204943001-Propyl-5-fluoropyrimid-2-oneYield 20%

Procedure

1-Propyl-5-fluoropyrimid-2-one was prepared as above from the potassium salt of 5-fluoropyrimid-2-one and n-propyl iodide in 20% yield after 48 hours; m.p. =93° C. (ligroin). (Found: C, 54.04; H, 5.82; Calc for C7H9FN2O: C, 53.86; H, 5.81).

Sources & evidence

ORD record
ord-538f11a3971643afb232101c5644a40d
Source dataset
uspto-grants-1983_07
Patent number
US04395406

Reaction notes

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