Iodoethane → HCID 178477361, compound

HRID 1075166Notes

Reaction equation

HRID 1075166 reaction equation
[K].[F:2][C:3]1[C:4](=[S:10])[NH:5][C:6](=[O:9])[NH:7][CH:8]=1.[CH2:11](I)[CH3:12]>CO>[CH2:11]([S:10][C:4]1[C:3]([F:2])=[CH:8][NH:7][C:6](=[O:9])[N:5]=1)[CH3:12]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 27812135-Fluoro-4-thiouracilHCID 5462222Potassium

Product 1

HCID 178477361HCID 178477361, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The potassium salt of 5-fluoro-4-thiouracil (0.0065 mol) and ethyl iodide (0.014 mol) in methanol (40 ml) were stirred at room temperature for 6 days. The solutions were concentrated at reduced pressure and water (6 ml) added. The slowly precipitated product was recrystallised from water; yield 70%, m.p. 168° C.

Workup

  1. concentrationThe solutions were concentrated at reduced pressure and water (6 ml)
  2. additionadded
  3. customThe slowly precipitated product was recrystallised from water

Sources & evidence

ORD record
ord-efc4cf14311f45f3a108de1fe99d8dba
Source dataset
uspto-grants-1983_07
Patent number
US04395406

Reaction notes

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