Hydrochloric Acid → HCID 178526043, compound

HRID 1075168Notes

Reaction equation

HRID 1075168 reaction equation
C([O:3][C:4]([CH2:6][S:7][C:8]1[C:13]([F:14])=[CH:12][NH:11][C:10](=[O:15])[N:9]=1)=[O:5])C.Cl>[OH-].[K+]>[C:4]([CH2:6][S:7][C:8]1[C:13]([F:14])=[CH:12][NH:11][C:10](=[O:15])[N:9]=1)([OH:5])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178473171HCID 178473171, compound

Product 1

HCID 178526043HCID 178526043, compoundYield 41%

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

4-Ethoxycarbonylmethylthio-5-fluoropyrimid-2-one (0.0013 mol) in 2 M potassium hydroxide (4 ml) was heated on a waterbath for 5-6 min. The solution was allowed to cool before neutralisation with dilute hydrochloric acid. The precipitated solid was recrystallised from methanol: yield 41%, m.p. 255° C.

Workup

  1. customThe precipitated solid was recrystallised from methanol

Sources & evidence

ORD record
ord-d9ba412572a149cb87ceef334b74ce45
Source dataset
uspto-grants-1983_07
Patent number
US04395406

Reaction notes

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