反应详情

温度

65 °C

A 1000 mL, round-bottomed flask equipped with air condensers and a magnetic stirring plate was charged with N,N-dimethyloctadecylamine (301.0 grams, 1.01 moles), 1-bromo-3-chloropropane (1700 grams, 1.08 moles) and methanol (200 mL). The reaction was maintained at 65° C. for 18 hours. Solvent was removed by rotary evaporation under reduced pressure to yield clear oil. The oil was transferred to a beaker containing methylethylketone (250 mL) causing a white precipitate to form. Solid material was collected by vacuum filtration, resuspended in methylethylketone (250 mL) and collected by vacuum filtration an additional two times. The solid was placed in a vacuum oven at 30° C. overnight. Yield 274.9 grams (0.59 moles, 58%).

1. customA 1000 mL, round-bottomed flask equipped with air condensers
2. customSolvent was removed by rotary evaporation under reduced pressure
3. customto yield clear oil
4. customto form
5. filtrationSolid material was collected by vacuum filtration
6. filtrationcollected by vacuum filtration an additional two times