HCID 13124491, compound → HCID 15428308, compound

HRID 1075645Notes

Reaction equation

HRID 1075645 reaction equation
C(OC([NH:11][C@H:12]1[C@H:15]([O:16][C:17](=[O:19])[CH3:18])[NH:14][C:13]1=[O:20])=O)C1C=CC=CC=1.[H][H]>[Pd].C(OCC)(=O)C>[NH2:11][C@H:12]1[C@H:15]([O:16][C:17](=[O:19])[CH3:18])[NH:14][C:13]1=[O:20]

Participants

5

Reactant 2

HCID 13124491HCID 13124491, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 15428308HCID 15428308, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

(3S,4S)-3-benzyloxycarbonylamino-4-acetoxy-azetidin-2-one (5.56 g, 20 mmole) was hydrogenated with 5.6 g of 10% palladium on activated carbon in ethyl acetate (120 ml) at 50 psi hydrogen pressure at room temperature for 1.5 hrs. After removal of catalyst by filtration, the deproteced (3S,4S)-3-amino-4-acetoxy-azetidin-2-one in ethyl acetate was obtained.

Workup

  1. customAfter removal of catalyst
  2. filtrationby filtration

Sources & evidence

ORD record
ord-edd06687fb134f6dbb17c71e04de33d0
Source dataset
uspto-grants-1999_05
Patent number
US05905076

Reaction notes

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