Hydrochloric Acid → 5-Fluorouracil

HRID 1075807Notes

Reaction equation

HRID 1075807 reaction equation
[F:1][CH:2]1[CH:7](OC)[NH:6][C:5](=[O:10])[NH:4][C:3]1=[O:11].Cl>>[F:1][C:2]1[C:3](=[O:11])[NH:4][C:5](=[O:10])[NH:6][CH:7]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 12610212HCID 12610212, compound

Product 1

HCID 33855-FluorouracilYield 49.9%

Procedure

0.25 g of 5-fluoro-6-methoxy-5,6-dihydrouracil obtained in Example 1B above was placed in a reflux flask and then 1 ml of concentrated HCl was added to the flask. The flask contents were brought to refluxing temperature, and the precipitation of a solid soon occurred, producing 0.1 g of 5-fluorouracil.

Workup

  1. temperatureto refluxing temperature
  2. customthe precipitation of a solid

Sources & evidence

ORD record
ord-350f13e7133944a0898dd29a0ffca105
Source dataset
uspto-grants-1976_05
Patent number
US03954759

Reaction notes

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