Hydrochloric Acid → 5-Fluorouracil

HRID 1075809Notes

Reaction equation

HRID 1075809 reaction equation
[F:1][CH:2]1[CH:7](OC(C)C)[NH:6][C:5](=[O:12])[NH:4][C:3]1=[O:13].Cl>>[F:1][C:2]1[C:3](=[O:13])[NH:4][C:5](=[O:12])[NH:6][CH:7]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 12829550HCID 12829550, compound

Product 1

HCID 33855-FluorouracilYield 74.9%

Procedure

0.41 g of 5-fluoro-6-isopropoxy-5,6-dihydrouracil was placed in a reflux flask and then 1 ml of concentrated HCl was added to the flask. Precipitation of a solid occurred a few minutes after reaching reflux conditions, yielding 0.21 g of 5-fluorouracil.

Workup

  1. customPrecipitation of a solid
  2. waitoccurred a few minutes
  3. temperatureafter reaching reflux conditions

Sources & evidence

ORD record
ord-9116ae8a2fa44260b8762b0867af63b3
Source dataset
uspto-grants-1976_05
Patent number
US03954759

Reaction notes

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