Hydrazine hydrate (1:1) → HCID 54489213, compound

HRID 1075934Notes

Reaction equation

HRID 1075934 reaction equation
[C:1]1([O:7][C:8]([N:10]2[CH2:20][CH2:19][C:13]3[N:14]=[N:15][C:16](Cl)=[CH:17][C:12]=3[CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.[NH2:22][NH2:23]>>[C:1]1([O:7][C:8]([N:10]2[CH2:20][CH2:19][C:13]3[N:14]=[N:15][C:16]([NH:22][NH2:23])=[CH:17][C:12]=3[CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 54330500HCID 54330500, compound

Product 1

HCID 54489213HCID 54489213, compound

Procedure

A solution of 20.3 g of crude oily 3-chloro-5,6,7,8-tetrahydro-6-pyrido[4,3-c]pyridazinecarboxylic acid phenyl ester in 100 cc of hydrazine hydrate is stirred in an oil bath of 100° for 11/2 hours. The reaction solution is concentrated in a vacuum and the residue is divided between 225 cc of chloroform and 25 cc of water. The crude title compound is obtained as semicrystalline residue upon concentrating the organic phase in a vacuum.

Workup

  1. concentrationThe reaction solution is concentrated in a vacuum

Sources & evidence

ORD record
ord-c2442c2e20304171bdb3b25104bb77ed
Source dataset
uspto-grants-1976_05
Patent number
US03954754

Reaction notes

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