Benzene → HCID 21541502, compound

HRID 1076017Notes

Reaction equation

HRID 1076017 reaction equation
[C:1]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[C:13](=[O:20])[CH2:14][CH:15]([OH:19])[C:16]=1OC)([O:3][CH2:4][CH3:5])=[O:2].C([Al](CC)CC)C.[CH:28]#[N:29].C1C=CC=CC=1>C1(C)C=CC=CC=1>[C:1]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[C:13](=[O:20])[CH2:14][CH:15]([OH:19])[C:16]=1[C:28]#[N:29])([O:3][CH2:4][CH3:5])=[O:2]

Participants

6

Reactant 4

HCID 241BenzeneHCID 768Hydrogen CyanideHCID 16682930TriethylaluminumHCID 21541489HCID 21541489, compound

Product 1

HCID 21541502HCID 21541502, compoundYield 44.4%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The procedure similar to that of Step 3 (a) of Example 1 was repeated using 9.4 g of 2-(6'-carbethoxyhexyl)-3-methoxy-4-hydroxy- 2-cyclopenten-1-one, 8.2 g of triethyl aluminum, 2.0 g of hydrocyanic acid, and a mixed solvent of benzene and toluene to provide 4.1 g of oily 2-(6'-carbethoxyhexyl)-3-cyano-4-hydroxy-2-cyclopenten-1-one.

Sources & evidence

ORD record
ord-203959e7dda84596a46156220ef412a8
Source dataset
uspto-grants-1976_05
Patent number
US03954811

Reaction notes

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