反应详情

In equation (1) the pseudourea of 2-thiopseudourea is liberated from its corresponding chloride or sulfate salt with an equivalent amount of sodium hydroxide in a mixture of water and dichloromethane at 0° to 5°C. The isocyanate or isothiocyanate is then added and after stirring for 1 to 24 hours at room temperature the organic layer is separated, dried, and the solvent removed by evaporation to give the intermediate allophanimidate, thioallophanimidate, or dithioallophanimidate ester (This reaction is essentially the same as described in Organic Synthesis, 42, 87, for the preparation of methyl 4-phenyl-3-thioallophanimidate.

1. customis separated
2. customdried
3. customthe solvent removed by evaporation