Chloride → HCID 178514107, Verbindung

HRID 1076042Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1076042
[NH2:1][C:2](=[NH:4])[OH:3].[NH2:5][C:6](=[NH:8])[SH:7].[Cl-].[OH-].[Na+].[N-:12]=[C:13]=[O:14].[N-]=C=S>O.ClCCl>[C:2](=[NH:1])([O-:3])[NH:4][C:13]([NH2:12])=[O:14].[C:6](=[NH:5])([S-:7])[NH:8][C:2]([NH2:1])=[O:3]

Komponenten

10

Edukt 6

HCID 312ChlorideHCID 14798Sodium HydroxideHCID 105034IsocyanateHCID 178418790HCID 178418790, VerbindungHCID 178513210HCID 178513210, VerbindungHCID 178513445HCID 178513445, Verbindung

Produkt 2

HCID 178514107HCID 178514107, VerbindungHCID 178514168HCID 178514168, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

In equation (1) the pseudourea of 2-thiopseudourea is liberated from its corresponding chloride or sulfate salt with an equivalent amount of sodium hydroxide in a mixture of water and dichloromethane at 0° to 5°C. The isocyanate or isothiocyanate is then added and after stirring for 1 to 24 hours at room temperature the organic layer is separated, dried, and the solvent removed by evaporation to give the intermediate allophanimidate, thioallophanimidate, or dithioallophanimidate ester (This reaction is essentially the same as described in Organic Synthesis, 42, 87, for the preparation of methyl 4-phenyl-3-thioallophanimidate.

Aufarbeitung

  1. customis separated
  2. customdried
  3. customthe solvent removed by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-5b65664f2b904eac969eac3fc683ea42
Quelldatensatz
uspto-grants-1976_05
Patentnummer
US03954837

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