Dimethylformamide → 5,6-Difluoro-1-indanone

HRID 107610Notes

Reaction equation

HRID 107610 reaction equation
[Cl:1][C:2]([C:3]([Cl:4])=[O:5])=[O:6].[Cl:25][CH2:26][Cl:27].[F:12][c:13]1[cH:14][c:15]([CH2:16][CH2:17][C:18](=[O:19])[OH:20])[cH:21][cH:22][c:23]1[F:24].[O:7]=[CH:8][N:9]([CH3:10])[CH3:11]>>[F:12][c:13]1[cH:14][c:15]2[c:21]([cH:22][c:23]1[F:24])[C:18](=[O:20])[CH2:17][CH2:16]2

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 65578Oxalyl chlorideHCID 27789943,4-Difluorohydrocinnamic acid

Product 1

HCID 117689445,6-Difluoro-1-indanone

Sources & evidence

ORD record
ord-e05b55693852477e9a4e6f145b62013a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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