Ammonium Hydroxide → HCID 21539659, compound

HRID 1076268Notes

Reaction equation

HRID 1076268 reaction equation
[CH3:1][C:2](=O)[CH2:3][C:4](=[O:6])[CH3:5].[OH-:8].[NH4+:9].[CH:10]([C:12]1[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][CH:13]=1)=O>C(O)C>[C:4]([C:3]1[CH:10]([C:12]2[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][CH:13]=2)[C:3]([C:4](=[O:6])[CH3:5])=[C:2]([CH3:1])[NH:9][C:2]=1[CH3:1])(=[O:8])[CH3:5]

Participants

5

Reactant 3

HCID 14923Ammonium HydroxideHCID 15294Methyl 4-FormylbenzoateHCID 31261Acetylacetone

Product 1

HCID 21539659HCID 21539659, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Twenty grams of 2,4-pentanedione and 17.5 ml. of ammonium hydroxide are added to 16.4 g. of methyl p-formylbenzoate in 120 ml. of ethanol and the resulting mixture is heated at reflux for five hours, then poured onto ice. The precipitated solid is filtered off and dried to give 3,5-diacetyl-4-(4-carbomethoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine.

Workup

  1. temperatureat reflux for five hours
  2. additionpoured onto ice
  3. filtrationThe precipitated solid is filtered off
  4. customdried

Sources & evidence

ORD record
ord-022f1603ea7a4fc5ba83e78e19afe333
Source dataset
uspto-grants-1976_05
Patent number
US03956341

Reaction notes

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