Formaldehyde → Ethyl 2-cyanopropionate

HRID 1076276Notes

Reaction equation

HRID 1076276 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4]CC1.C1(C=[CH:13][C:11]([OH:12])=CC=1)O.[CH2:15]=[O:16]>C(O)(=O)C>[C:6]([CH:5]([CH3:4])[C:15]([O:12][CH2:11][CH3:13])=[O:16])#[N:1]

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 785HydroquinoneHCID 8082Piperidine2×

Product 1

HCID 98018Ethyl 2-cyanopropionate

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Following the procedure of Example 5 omitting the 0.25 parts of piperidine and 0.025 parts of hydroquinone and adding 9.6 parts of the formalin, piperidine and acetic acid solution in place of the 8.6 parts of Example 5 over 151/4 hours gave 6.8 parts of ethyl 2-cyanopropionate of boiling point 82-90°C/8 mm. of mercury.

Sources & evidence

ORD record
ord-df45aab7782446b0baa7307781cf6959
Source dataset
uspto-grants-1976_05
Patent number
US03956357

Reaction notes

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