Formaldehyde → HCID 53812917, compound

HRID 1076380Notes

Reaction equation

HRID 1076380 reaction equation
ClC[C:3]1[CH:12]=C[C:10]2[C:5](=CC=CC=2)[N:4]=1.[CH3:13][O:14][CH:15]([C:20]1[CH:29]=[CH:28][C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[N:21]=1)[C:16]([NH:18][CH3:19])=[S:17].[C:30](N)(=S)C.C=O.C(NCC)C>>[CH2:5]([N:4]([CH2:3][CH3:12])[CH2:30][C:15]([O:14][CH3:13])([C:20]1[CH:29]=[CH:28][C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[N:21]=1)[C:16]([NH:18][CH3:19])=[S:17])[CH3:10]

Participants

6

Reactant 5

HCID 712FormaldehydeHCID 8021DiethylamineHCID 203942-(Chloromethyl)quinolineHCID 2723949ThioacetamideHCID 21486872HCID 21486872, compound

Product 1

HCID 53812917HCID 53812917, compound

Procedure

By the procedure of Example 1, using 2-(chloromethyl)quinoline in place of 2-(chloromethyl)pyridine, 2-methoxy-N-methyl-2-(2-quinolyl)thioacetamide is prepared. Reacting this thioacetamide with formaldehyde and diethylamine gives 3-diethylamino-2-methoxy-N-methyl-2-(2-quinolyl)thiopropanamide.

Workup

  1. customis prepared

Sources & evidence

ORD record
ord-22c62b092c114c1cb1739ebccbbd0f47
Source dataset
uspto-grants-1976_05
Patent number
US03956494

Reaction notes

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