Hydrazine hydrate (1:1) → Benzodiazepine

HRID 1076630Notes

Reaction equation

HRID 1076630 reaction equation
[NH:1]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH:5]=NC=C1.ClC1C=CC=CC=1C(=O)C1C=[C:24]([N+:26]([O-])=O)[CH:23]=CC=1N1C(CN2C(=O)C3=CC=CC=C3C2=O)=NN=C1CN(C)C.O.NN>C(O)C>[NH:1]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH:5]=[CH:23][CH:24]=[N:26]1

Participants

5

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 1484311H-1,4-BenzodiazepineHCID 21537264HCID 21537264, compound

Product 1

HCID 134664Benzodiazepine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner [1,4]benzodiazepin. in Example 27, 2'-chloro-5-nitro2-[3-[(dimethylamino)methyl]-5-(phthalimidomethyl)-4H-1,2,4triazol-4-yl]benzophenone is heated in ethanol with hydrazine hydrate to give 8-nitro-1-[(dimethylamino)methyl] -6-(o-chlorophenyl)-4H-s-triazolo[4,3-a]1,4]benzodiazepin.

Sources & evidence

ORD record
ord-b23d7f7f3b7c46969489a565b1e3d5b2
Source dataset
uspto-grants-1976_05
Patent number
US03957761

Reaction notes

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