Potassium Carbonate → HCID 12235833, compound

HRID 1076673Notes

Reaction equation

HRID 1076673 reaction equation
[Cl-].[NH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N+:4]=1[CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=1Br.C(=O)([O-])[O-].[K+].[K+]>[Cu].C(O)CC>[Cl:17][C:14]1[CH:13]=[CH:12][C:11]2[O:10][CH2:9][N:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:3]3=[N:2][C:16]=2[CH:15]=1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 22752754HCID 22752754, compound

Product 1

HCID 12235833HCID 12235833, compoundYield 73.1%

Reagents, catalysts & solvents 2

HCID 23978CopperCatalystHCID 10311-PropanolSolvent

Procedure

A mixture of 14.0 g of 2-amino-1-[(2-bromo-4-chlorophenoxy)methyl]pyridinium chloride, 11.1 g of micronized, anhydrous potassium carbonate, 0.4 g of copper bronze, and 350 ml of anhydrous n-propanol is stirred and heated under reflux for about eight hours, filtered hot, and the deep yellow filtrate is concentrated to dryness in vacuo. Workup gives about 6.8 g of 2-chloro-6H-pyrido[1,2-c][1,3,5]-benzoxadiazepine, m.p. about 175°-177°.

Workup

  1. temperatureheated
  2. temperatureunder reflux for about eight hours
  3. filtrationfiltered hot
  4. concentrationthe deep yellow filtrate is concentrated to dryness in vacuo

Sources & evidence

ORD record
ord-fc856531fe3d4f8c82eefd32f68af279
Source dataset
uspto-grants-1976_05
Patent number
US03957806

Reaction notes

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