Hydrazine hydrate (1:1) → HCID 178422220, compound

HRID 1076696Notes

Reaction equation

HRID 1076696 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]=[C:8]2[CH2:17][CH:16]([CH3:18])[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]2=O)=[CH:3][CH:2]=1.O.[NH2:21][NH2:22]>C(O)(C)C>[CH3:18][CH:16]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]2=[N:21][NH:22][C:7]([C:4]3[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=3)=[C:8]2[CH2:17]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 54142473HCID 54142473, compound

Product 1

HCID 178422220HCID 178422220, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

To 24.0 grams (0.1 oles) of the compound of Step A of this exampel in a flask equipped with stirrer and condenser are added 4.8 grams (0.15 Mole) of hydrazine hydrate (95%) and 150 ml. of isopropanol. The mixture is stirred and refluxed for about 24 hours and the solvent is then crystallized from methanol to given 4,5-dihydro-5-methyl-3-(4-pyridyl)-2h-naphtho[1,2-c]pyrazole.

Workup

  1. temperaturerefluxed for about 24 hours
  2. customthe solvent is then crystallized from methanol

Sources & evidence

ORD record
ord-1578e1c577e9402caf9e0423f5b69746
Source dataset
uspto-grants-1976_05
Patent number
US03957816

Reaction notes

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