p-Toluenesulfonic acid → HCID 178520831, compound

HRID 1076717Notes

Reaction equation

HRID 1076717 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][OH:5].[F:6][C:7]1[CH:8]=[C:9]([C:13]2([OH:23])[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[NH:15][C:14]2=O)[CH:10]=[CH:11][CH:12]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[F:6][C:7]1[CH:8]=[C:9]([C:13]2([OH:23])[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=[C:14]2[NH:1][CH2:2][CH2:3][CH2:4][OH:5])[CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 3

HCID 6101p-Toluenesulfonic acidHCID 90863-Amino-1-propanolHCID 21537963HCID 21537963, compound

Product 1

HCID 178520831HCID 178520831, compound

Procedure

Reaction of 3-aminopropanol with 3-(m-fluorophenyl)-3-hydroxy-3H-indol-2-one in presence of toluene-p-sulphonic acid by a procedure analogous to that of Example 1 gives 3-(m-fluorophenyl)-2-(3-hydroxypropylamino)-3H-indol-3-ol.

Sources & evidence

ORD record
ord-a8acf1cce7cd428f977c5a769d8734b3
Source dataset
uspto-grants-1976_05
Patent number
US03957819

Reaction notes

Loading…