p-Toluenesulfonic acid → HCID 178520832, compound

HRID 1076719Notes

Reaction equation

HRID 1076719 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][OH:5].[Cl:6][C:7]1[CH:8]=[C:9]([C:14]2([OH:24])[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[NH:16][C:15]2=O)[CH:10]=[CH:11][C:12]=1[Cl:13].C1(C)C=CC(S(O)(=O)=O)=CC=1>>[Cl:6][C:7]1[CH:8]=[C:9]([C:14]2([OH:24])[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[N:16]=[C:15]2[NH:1][CH2:2][CH2:3][CH2:4][OH:5])[CH:10]=[CH:11][C:12]=1[Cl:13]

Participants

4

Reactant 3

HCID 6101p-Toluenesulfonic acidHCID 90863-Amino-1-propanolHCID 5297664HCID 5297664, compound

Product 1

HCID 178520832HCID 178520832, compound

Procedure

Reaction of 3-aminopropanol with 3-(3,4-dichlorophenyl)-3-hydroxy-3H-indol-2-one in presence of toluene-p-sulphonic acid by a procedure analogous to that of Example 1 gives 3-(3,4-dichlorophenyl)-2-(3-hydroxypropylamino)-3H-indol-3-ol

Sources & evidence

ORD record
ord-73bfead7ed3b47a78513be58f68e6539
Source dataset
uspto-grants-1976_05
Patent number
US03957819

Reaction notes

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