p-Toluenesulfonic acid → HCID 178520829, compound

HRID 1076722Notes

Reaction equation

HRID 1076722 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][OH:5].[OH:6][C:7]1([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=2)[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[NH:9][C:8]1=O.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[OH:5][CH2:4][CH2:3][CH2:2][NH:1][C:8]1[C:7]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:24])([F:26])[F:25])[CH:18]=2)([OH:6])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=1

Participants

4

Reactant 3

HCID 6101p-Toluenesulfonic acidHCID 90863-Amino-1-propanolHCID 21516639HCID 21516639, compound

Product 1

HCID 178520829HCID 178520829, compound

Procedure

Reaction of 3-aminopropanol with 3-hydroxy-(3-(m-trifluoromethylphenyl)-)-3H-indol-2-one in presence of toluene-p-sulphonic acid by a procedure analogous to that of Example 1 gives 2-(3-hydroxypropylamino)-3-(m-trifluoromethylphenyl)-3H-indol-3-ol.

Sources & evidence

ORD record
ord-b54895305cd04b65ac06e28747288e3d
Source dataset
uspto-grants-1976_05
Patent number
US03957819

Reaction notes

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