2-(6-Methoxy-2-naphthyl)propionic acid → 37414-52-1

HRID 1076879Notes

Reaction equation

HRID 1076879 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].C(OCC)C.[CH3:12][O:13][C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][CH:23]=1)[CH:20]=[C:19]([CH:24]([CH3:28])[C:25](O)=[O:26])[CH:18]=[CH:17]2.C(OCC)(=O)C>O>[CH3:12][O:13][C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][CH:23]=1)[CH:20]=[C:19]([CH:24]([CH3:28])[CH2:25][OH:26])[CH:18]=[CH:17]2

Participants

6

Reactant 4

HCID 13022-(6-Methoxy-2-naphthyl)propionic acidHCID 3283Diethyl Ether2×HCID 8857Ethyl AcetateHCID 21226445Aluminium lithium hydride

Product 1

HCID 3334137414-52-1

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
0 °C

Procedure

To a mixture of 0.4 g. of lithium aluminum hydride and 100 ml. of ethyl ether, there is added a mixture of 2.3 g. of d 2-(6-methoxy-2-naphthyl)propionic acid and 100 ml. of ethyl ether. The mixture is stirred at 0°C for 30 minutes, and 10 ml. of ethyl acetate is added. After 1 hour, 4 ml. of water is added to the mixture. The resulting mixture is filtered and evaporated under reduced pressure to yield l 2-(6-methoxy-2-naphthyl)-l-propanol.

Workup

  1. additionTo a mixture of 0.4 g
  2. additiona mixture of 2.3 g
  3. waitAfter 1 hour
  4. filtrationThe resulting mixture is filtered
  5. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-b381236aa1e845b3ab93dac1c1593394
Source dataset
uspto-grants-1976_05
Patent number
US03958012

Reaction notes

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