反应详情

Toluene-α-thiol (1.0 ml.) was added to a warm solution of sodium (0.6 g.) in a mixture of propan-2-ol (25 ml.) and toluene (30 ml.). 21-Bromo-3α-hydroxy-5α-pregnane-11,20 -dione (0.7 g.) was then added and the mixture was gently refluxed for 2 hr. The mixture was then partitioned between water and ether and the organic layer was washed with water, dried (Na2SO4) and evaporated. The residue was purified by preparative t.l.c. (CHCl3) to give title compound (0.4 g.) as a white foam, [α]D + 89° (c 1.1).

1. temperaturethe mixture was gently refluxed for 2 hr
2. customThe mixture was then partitioned between water and ether
3. washthe organic layer was washed with water
4. dry with materialdried (Na2SO4)
5. customevaporated
6. customThe residue was purified by preparative t.l.c