反应详情

To a solution of 1-piperidin-4-yl-1H-indole (0.6 g, 3 mmol) in 5 mL of dry ethanol was added anhydrous potassium carbonate (680 mg, 4.9 mmol). After stirring for 15 minutes at ambient temperature, ethyl p-toluenesulfonate (0.48 mL,4.5 mmol) was added. The reaction was heated under reflux for 24 hours with stirring, quenched with water, extracted with methylene chloride (2×), dried and evaporated to give a residue. The residue was chromatographed on silica gel with toluene/acetone (50:50) to yield 360 mg straw colored material (53% of theory).

1. temperatureThe reaction was heated
2. temperatureunder reflux for 24 hours
3. stirringwith stirring
4. customquenched with water
5. extractionextracted with methylene chloride (2×)
6. customdried
7. customevaporated
8. customto give a residue
9. customThe residue was chromatographed on silica gel with toluene/acetone (50:50)
10. customto yield 360 mg straw colored material (53% of theory)