Aminopyridazine → HCID 10087298, compound

HRID 1078017Notes

Reaction equation

HRID 1078017 reaction equation
[CH3:1][N:2]([CH2:18][C:19]1[CH:24]=[CH:23][N:22]=C[CH:20]=1)[C:3]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[C:9]2[C:4]=1[CH:5]=[CH:6][CH:7]=[C:8]2[C:16]#[N:17].ClC1C=CC([N+:36]([O-])=O)=C2C=1C=CC=C2C#N.N1C=CC=C(N)N=1>>[CH3:1][N:2]([CH2:18][C:19]1[CH:24]=[CH:23][N:22]=[N:36][CH:20]=1)[C:3]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[C:9]2[C:4]=1[CH:5]=[CH:6][CH:7]=[C:8]2[C:16]#[N:17]

Participants

4

Reactant 3

HCID 230373AminopyridazineHCID 9991568HCID 9991568, compoundHCID 10087232HCID 10087232, compound

Product 1

HCID 10087298HCID 10087298, compoundYield 24%

Procedure

5-(Methyl-pyridazin-4-ylmethyl-amino)-8-nitro-naphthalene-1-carbonitrile (24) was prepared in a manner analogous to that described above for the preparation of compound (10), except that compound (9) and pyridazyl amine compound (48) were used as starting materials. Compound (24) (24% yield) was isolated as a yellow foam by flash chromatography on silica, eluting CH2Cl2 :MeOH (25:1).

Workup

  1. custom5-(Methyl-pyridazin-4-ylmethyl-amino)-8-nitro-naphthalene-1-carbonitrile (24) was prepared in a manner analogous to

Sources & evidence

ORD record
ord-f0399058573940ebaa4f12d576aa5596
Source dataset
uspto-grants-1996_08
Patent number
US05545744

Reaction notes

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