反应详情

A reaction vessel was charged with 19.4 g of 2-fluoro-4-bromophenol, 16.8 g of hexyl bromide, 23.3 g of potassium carbonate and 510 ml of cyclohexanone and the reaction was effected with stirring at 120°-140° C. for 7 hours. The reaction liquid was poured into dilute hydrochloric acid and the mixture was extracted with benzene. The benzene layer was washed with water and dried over Glauber's salt, and the benzene was distilled off. The residue was purified by way of column chromatography on silica gel (eluent: hexane) to obtain 23.4 g (yield 83.6%) of 3-fluoro-4-hexyloxybromobenzene.

1. customThe reaction liquid
2. extractionthe mixture was extracted with benzene
3. washThe benzene layer was washed with water
4. dry with materialdried over Glauber's salt
5. distillationthe benzene was distilled off
6. customThe residue was purified by way of column chromatography on silica gel (eluent: hexane)