反应详情

温度

180 °C

70 g (0.2 mol) of octadecyltrimethylammonium chloride were dissolved in a melt of 2020 g (10.5 mol) of 3,4-dichloronitrobenzene at 50° C. with stirring, 580 g (10.0 mol) of potassium fluoride were suspended at 100° C. and this suspension was heated to 180° C. for 9 h. After cooling to about 60° C., the reaction suspension was filtered with suction, the liquid adhering to the residue was distilled off at 150° C./70 torr and the combined organic phases were fractionated with the addition of an auxiliary base as an acid scavenger. 1445 g (90.6%, relative to 3,4-dichloronitrobenzene converted) of 3-chloro-4-fluoronitrobenzene and 324 g (13.6%, relative to 3,4-dichioronitrobenzene employed) of unreacted 3,4-dichloronitrobenzene were obtained.

1. customwere suspended at 100° C.
2. temperatureAfter cooling to about 60° C.
3. filtrationthe reaction suspension was filtered with suction
4. distillationthe liquid adhering to the residue was distilled off at 150° C./70 torr
5. additionthe combined organic phases were fractionated with the addition of an auxiliary base as an acid scavenger