反应详情

温度

100 °C

A mixture of methyl 4,6-dichloropyrimidin-5-yl-acetate (221 g, 1 mol), 3-hydroxyacetophenone (136 g, 1 mol) and K2CO3 (207 g, 1.5 mol) in DMF (150 mol) is stirred at 100° C. for 90 minutes. The dark mixture is cooled to 0° C. and dimethylamine (450 ml of a 40% aqeous solution) is added. Stirring is continued at room temperature for hours. Dilution with water and extraction with ether gives methyl 4-(3-acetylphenoxy)-6-dimethylamino-pyrimidin-5-yl-acetate as a brownish oil (purity>95%).

1. temperatureThe dark mixture is cooled to 0° C.
2. stirringStirring
3. waitis continued at room temperature for hours
4. extractionDilution with water and extraction with ether