Ethanol → 3-(2-Methyl-1,3-dioxolan-2-yl)-1-propanamine

HRID 1078338Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1078338
[CH2:1]1[O:20][C:4]([CH2:6][CH2:7][CH2:8][N:9]2C(=O)C3=CC=CC=C3C2=O)([CH3:5])[O:3][CH2:2]1.C(O)C.CCOCC.[OH-].[K+]>O>[CH2:1]1[O:20][C:4]([CH2:6][CH2:7][CH2:8][NH2:9])([CH3:5])[O:3][CH2:2]1

Komponenten

6

Edukt 4

HCID 702EthanolHCID 3283Diethyl EtherHCID 14797Potassium HydroxideHCID 8222852-[3-(2-Methyl-1,3-dioxolan-2-yl)propyl]isoindole-1,3-dione

Produkt 1

HCID 5600073-(2-Methyl-1,3-dioxolan-2-yl)-1-propanamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Seventy-one grams of 5-phthalimido-2-pentanone ethylene ketal (0.26 moles) were suspended into 250 ml of 95% ethanol. Then 13.0 g of NH2 ·NH2 ·H2O (0.26 moles) was added and the reaction mixture was brought to reflux. The stirred mixture was refluxed for 2 hours. Ether (400 ml) was added to the cooled suspension, which was then treated with 40 g of potassium hydroxide in 150 ml of water. The two layers were separated and the aqueous The ether was combined and dried over sodium sulfate. The solvent was then removed under pressure and the remaining liquid that contained crude product was weighed.

Aufarbeitung

  1. temperatureto reflux
  2. temperatureThe stirred mixture was refluxed for 2 hours
  3. customThe two layers were separated
  4. dry with materialdried over sodium sulfate
  5. customThe solvent was then removed under pressure

Quellen und Nachweise

ORD-Eintrag
ord-b81501ff988741f0b72d564ff87b5484
Quelldatensatz
uspto-grants-1996_08
Patentnummer
US05547982

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