反应详情

108 ml of a 40% strength aqueous solution of methylamine were dissolved in 300 ml of tetrahydrofuran. 53 g of 3,4-dimethylbenzoyl chloride were added dropwise to this solution with ice cooling. The reaction mixture was subsequently stirred at room temperature for 1 hour. Then the reaction mixture was concentrated to half its volume under reduced pressure, saturated sodium chloride solution was added, and the mixture was acidified with concentrated hydrochloric acid. The product which then precipitated was filtered out with suction and dried at 40° C. over potassium hydroxide in a drying cabinet. 47 g of N-methyl-3,4-dimethylbenzamide were obtained.

1. concentrationThen the reaction mixture was concentrated to half its volume under reduced pressure, saturated sodium chloride solution
2. additionwas added
3. customThe product which then precipitated
4. filtrationwas filtered out with suction
5. dry with materialdried at 40° C. over potassium hydroxide in a drying cabinet