Borane;tetrahydrofuran → HCID 19429375, compound

HRID 1078392Notes

Reaction equation

HRID 1078392 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([NH:11][C:12](=O)[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][N:20]2[CH:24]=[CH:23][N:22]=[CH:21]2)([CH3:10])[CH3:9])=[CH:4][CH:3]=1.B.C1COCC1>C1COCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][N:20]2[CH:24]=[CH:23][N:22]=[CH:21]2)([CH3:10])[CH3:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 2723981Borane;tetrahydrofuranHCID 19429455HCID 19429455, compound

Product 1

HCID 19429375HCID 19429375, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a similar manner to Example 52d, a solution of N-[1-(4-chlorophenyl)-1-methylethyl]-8-(imidazol-1-yl)octanamide (5.9 g) in THF (130 ml) was reduced with BH3/THF (64.5 ml of a 1M solution) to give N-[1-(4-chlorophenyl)-1-methylethyl]-8-(imidazol-1-yl)octylamine, b.p. 210° C. (0.05 mmHg).

Sources & evidence

ORD record
ord-d1a7d4c714c94a28b646e1624ebf0e25
Source dataset
uspto-grants-1996_08
Patent number
US05547972

Reaction notes

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