L-Tartaric acid → HCID 86749735, compound

HRID 1078404Notes

Reaction equation

HRID 1078404 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([NH:11][CH2:12][CH2:13][CH2:14][N:15]2[CH:19]=[CH:18][N:17]=[CH:16]2)([CH3:10])[CH3:9])=[CH:4][CH:3]=1.[C:20]([OH:29])(=[O:28])[C@@H:21]([C@H:23]([C:25]([OH:27])=[O:26])[OH:24])[OH:22]>>[OH2:22].[OH2:22].[C:25]([CH:23]([CH:21]([C:20]([OH:29])=[O:28])[OH:22])[OH:24])([OH:27])=[O:26].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([NH:11][CH2:12][CH2:13][CH2:14][N:15]2[CH:19]=[CH:18][N:17]=[CH:16]2)([CH3:10])[CH3:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 444305L-Tartaric acidHCID 9863253HCID 9863253, compound

Product 1

HCID 86749735HCID 86749735, compound

Procedure

N-[1-(4-Chlorophenyl)-1-methylethyl]-3-(imidazol-1-yl)propylamine (2.57 g) and L-(+)-tartaric acid (1.39 g) were dissolved in warm IMS (10 ml) and allowed to cool. On scratching a salt crystallised. The salt was collected by filtration and recrystallised from IMS to give N-[1-(4-chlorophenyl)-1-methylethyl]-3-(imidazol-1-yl)propylamine (+)tartrate dihydrate, m.p. 76°-78° C.

Workup

  1. temperatureto cool
  2. customcrystallised
  3. filtrationThe salt was collected by filtration
  4. customrecrystallised from IMS

Sources & evidence

ORD record
ord-af4fb97e00dd478d84951f8bed2392b8
Source dataset
uspto-grants-1996_08
Patent number
US05547972

Reaction notes

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