Triethylamine → N-[1-(4-chlorophenyl)ethyl]acrylamide

HRID 1078419Notes

Reaction equation

HRID 1078419 reaction equation
[C:1](Cl)(=[O:4])[CH:2]=[CH2:3].[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([CH:13]([NH2:15])[CH3:14])=[CH:9][CH:8]=1.C(N(CC)CC)C>ClCCl>[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([CH:13]([NH:15][C:1](=[O:4])[CH:2]=[CH2:3])[CH3:14])=[CH:9][CH:8]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 13140Acryloyl chlorideHCID 978031-(4-Chlorophenyl)ethylamine

Product 1

HCID 19429535N-[1-(4-chlorophenyl)ethyl]acrylamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a similar manner to Example 62a, a mixture of acryloyl chloride (58.2 g) was added to 1-(4-chlorophenyl)ethylamine (100 g) and triethylamine (65.2 g) in dichloromethane (400 ml) to give N-[1-(4-chlorophenyl)ethyl]acrylamide, m.p. 103°-104° C.

Sources & evidence

ORD record
ord-ddfa316e95ac4ef8ac81c3f15efd662e
Source dataset
uspto-grants-1996_08
Patent number
US05547972

Reaction notes

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