1-Phenylpiperazine → 5,6,7-trimethoxy-4-methyl-3-[2-(4-phenyl-1-piperazinyl)ethyl]-2H-1-benzopyran-2-one

HRID 1078587Notes

Reaction equation

HRID 1078587 reaction equation
CS(O[CH2:6][CH2:7][C:8]1[C:9](=[O:25])[O:10][C:11]2[CH:18]=[C:17]([O:19][CH3:20])[C:16]([O:21][CH3:22])=[C:15]([O:23][CH3:24])[C:12]=2[C:13]=1[CH3:14])(=O)=O.[C:26]1([N:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>CC(OC)(C)C.C(O)(C)C>[CH3:24][O:23][C:15]1[C:12]2[C:13]([CH3:14])=[C:8]([CH2:7][CH2:6][N:35]3[CH2:36][CH2:37][N:32]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[CH2:33][CH2:34]3)[C:9](=[O:25])[O:10][C:11]=2[CH:18]=[C:17]([O:19][CH3:20])[C:16]=1[O:21][CH3:22]

Participants

4

Reactant 2

HCID 70961-PhenylpiperazineHCID 194281663-[2-(methanesulphonyloxy)ethyl]-5,6,7-trimethoxy-4-methyl-2H-1-benzopyran-2-one

Product 1

HCID 194281275,6,7-trimethoxy-4-methyl-3-[2-(4-phenyl-1-piperazinyl)ethyl]-2H-1-benzopyran-2-oneYield 49%

Reagents, catalysts & solvents 1

HCID 86616950TBME isopropanolSolvent

Procedure

Process B; starting materials: 3-[2-(methanesulphonyloxy)ethyl]-5,6,7-trimethoxy-4-methyl-2H-1-benzopyran-2-one (Example 34) and 1-phenylpiperazine; yield 49%; m.p. 136°-137° C. (from TBME/isopropanol).

Sources & evidence

ORD record
ord-8cd34af96ec84c7dbd4a9b49345a84fc
Source dataset
uspto-grants-1996_08
Patent number
US05550129

Reaction notes

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