Hydrochloric Acid → HCID 70277877, compound

HRID 1078726Notes

Reaction equation

HRID 1078726 reaction equation
C(OC([N:8]1[CH2:12][C@H:11]([O:13][Si](C(C)(C)C)(C)C)[CH2:10][C@H:9]1[C:21](=[O:32])[CH2:22][CH2:23][O:24][Si](C(C)(C)C)(C)C)=O)(C)(C)C.CO.[ClH:35]>>[ClH:35].[OH:13][C@H:11]1[CH2:12][NH:8][C@H:9]([C:21](=[O:32])[CH2:22][CH2:23][OH:24])[CH2:10]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 22865014HCID 22865014, compound

Product 1

HCID 70277877HCID 70277877, compound

Procedure

(2S,4R)-N-tert-Butoxycarbonyl-4-tert-butyldimethylsiloxy-2-(3-tert-butyldimethylsiloxy-1-oxopropyl)pyrrolidine (4.87 g, 10.0 mmol) was dissolved in a 3.3N hydrogen chloride--methanol solution (16.5 ml). The solution was stirred at room temperature for 24 h, and then concentrated in vacuo to obtain the title compound (2.29 g).

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-68f60f7885c845d7b9a48238786ac111
Source dataset
uspto-grants-1996_08
Patent number
US05550121

Reaction notes

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