Tetrahydrofuran → Piperidine, 1-[2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-1,2-dioxoethyl]-4-(phenyl-2-thiazolylmethylene)-

HRID 107879Notes

Reaction equation

HRID 107879 reaction equation
[Br:1][C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)=[C:9]1[CH2:10][CH2:11][N:12]([C:15]([C:16](=[O:17])[c:18]2[cH:19][nH:20][c:21]3[c:22]([O:29][CH3:30])[n:23][cH:24][c:25]([O:27][CH3:28])[c:26]23)=[O:31])[CH2:13][CH2:14]1.[CH2:32]([Sn:33]([CH2:34][CH2:35][CH2:36][CH3:42])([c:37]1[s:38][cH:39][cH:40][n:41]1)[CH2:43][CH2:44][CH2:45][CH3:46])[CH2:47][CH2:48][CH3:49].[CH2:50]1[O:51][CH2:52][CH2:53][CH2:54]1.[CH3:55][CH2:56][O:57][C:58]([CH3:59])=[O:60]>>[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)(=[C:9]1[CH2:10][CH2:11][N:12]([C:15]([C:16](=[O:17])[c:18]2[cH:19][nH:20][c:21]3[c:22]([O:29][CH3:30])[n:23][cH:24][c:25]([O:27][CH3:28])[c:26]23)=[O:31])[CH2:13][CH2:14]1)[c:37]1[s:38][cH:39][cH:40][n:41]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 27632592-(Tributylstannyl)-1,3-thiazoleHCID 5279817Piperidine, 4-(bromophenylmethylene)-1-[2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-1,2-dioxoethyl]-

Product 1

HCID 5279858Piperidine, 1-[2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-1,2-dioxoethyl]-4-(phenyl-2-thiazolylmethylene)-

Sources & evidence

ORD record
ord-dbf533068e33428dae8bbd0eb8c04506
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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