Oxalic Acid → (RS)-2-methyl-4-methylidene-3-(2,2,2-trifluoroethyl)cyclopent-2-en-1-ol

After 10.5 g of (RS)-2-methyl-4-methylidene-3-(2,2,2-trifluoroethyl)-1-t-butyldimethylsilyloxy-2-cyclopentene was dissolved in 50 ml of dry tetrahydrofuran, a mixture of 10.5 ml of a 1M tetrabutylammonium fluoride/tetrahydrofuran solution and 5 ml of hydrofluoric acid was added under cooling and stirred at ambient temperatures for twelve hours. The reaction solution was then added to 100 ml of an ice-cooled 5% aqueous oxalic acid, and extracted with diethyl ether (300 ml×3 times). The combined ether layer was washed successively with a saturated sodium hydrogencarbonate solution and a saturated sodium chloride solution, and dried over anhydrous magnesium sulfate. After removal of the solvent under reduced pressure, the residue was treated by silica gel column chromatography (eluent: n-hexane:ethyl acetate=3:1 (v/v)) to yield 5.27 g of (RS)-2-methyl-4-methylidene-3-(2,2,2-trifluoroethyl)cyclopent-2-en-1-ol.

1. additionwas added
2. temperatureunder cooling
3. extractionextracted with diethyl ether (300 ml×3 times)
4. washThe combined ether layer was washed successively with a saturated sodium hydrogencarbonate solution
5. dry with materiala saturated sodium chloride solution, and dried over anhydrous magnesium sulfate
6. customAfter removal of the solvent under reduced pressure
7. additionthe residue was treated by silica gel column chromatography (eluent: n-hexane:ethyl acetate=3:1 (v/v))

ORD record

ord-ca9ecf1dd4c74585a01505aaa3820f00

Source dataset

uspto-grants-1996_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05550258